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Peptide record

TPDB92847

TAT (dcHGT) Cell-penetrating Peptides standard
11 amino acids
Basic Information
3D PDB MODEL
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TPDB92847
TAT (dcHGT)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD-MOD CPPsite3.0 Peptipedia PerseuCPP
standard
No
A 11-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD-MOD, CPPsite3.0, Peptipedia, and other sources, with an available 3D structural model.
Chemical: Monosialotetrahexosylganglioside (GM1)
Sequence
GRKKRRQRRRG
Physicochemical Analysis
C57H112N32O13
ANDCEHILMFPSTWYV
R
1453.72
13.10
8
0
0
+8
7.44
-3.555
0.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
0
A
6
R
0
N
0
D
0
C
0
E
1
Q
2
G
0
H
0
I
0
L
2
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 2 H: 0 I: 0 L: 0 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
11
C57H112N32O13
1453.72
13.10
+8
7.44
-3.555
Free
Monosialotetrahexosylganglioside (GM1)
L
Cationic
Linear
Free
N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)O)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Bv-2 Cells

Assay & Model

AD mice
AD mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Protein derived
Clioquinol (metal-ion chelating agent) and donepezil (acetylCHOlinesterase (AChE) inhibitor) co-encapsulated human serum albumin (HSA) nanoparticles (Cy5-labelled dcHGT NPs)
Cells treated with dcHGT NPs exhibited 2.15 times stronger red fluorescence signals than dcHT NPs
Caveolae mediated endocytosis
In vitro and in vivo
CCCCCCSCCCCSSSCSSCTTCTTTC
Additional Detail Fields 1 fields
CCCCCCSCCCCSSSCSSCTTCTTTC