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Peptide record

TPDB92840

CADY-2 Cell-penetrating Peptides standard
20 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB92840
CADY-2
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD CellPPD-MOD CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP
standard
No
A 20-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD, CellPPD-MOD, CPPsite3.0, and other sources, with an available 3D structural model.
C-terminal: Cysteamidation N-terminal: Acetylation
Sequence
Ac-GLWWRLWWRLRSWFRLWFRA
Physicochemical Analysis
C146H197N41O22
NDCEQHIKMPTYV
W
2878.43
13.00
5
0
13
+5
-11.58
-0.325
83.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
33000
1146.46
1
Residue Composition
number
1
A
5
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
4
L
0
K
0
M
2
F
0
P
1
S
0
T
6
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 5 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 4 K: 0 M: 0 F: 2 P: 0 S: 1 T: 0 W: 6 Y: 0 V: 0
Chemical Descriptors
20
C146H197N41O22
2878.43
13.00
+5
-11.58
-0.325
Cysteamidation
L
Amphipathic
Linear
Acetylation
N[C@@H](CS)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)O NCC(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCN[C@H](C)CCC)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)O N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)O
Evidence Records 3 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Hek-293T

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
GFP protein and FITC-antibody
Cytoplasm
Deliver FITC-antibody significantly more highly than GFP
In vitro
CCCCCCCCCCSSSSSCC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

Hek-293T

Assay & Model

C57BL/6 female mice, 5–7 week old
C57BL/6 female mice, 5–7 week old

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Amphipathic
Protein derived
HPV E7 oncoprotein
Transfer E7 protein into the cells
In vitro and in vivo
CCSSCCCSCTTCSCCSSTTTTTGGGTCSCCCGGGGTCCSSCSSCSSCC
Evidence 3 Activity

Activity

Cell-penetrating Peptides

Target

Hek-293 T Cells

Assay & Model

Five to seven week-old female BALB/c mice
Five to seven week-old female BALB/c mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Amphipathic
Synthetic
rNS3 or rHsp27-NS3 protein nanoparticles
Transfer NS3 and Hsp27-NS3 proteins into the cells
In vitro and in vivo
CTTCCBTTBC
Additional Detail Fields 1 fields
CCCCCCCCCCSSSSSCC CCSSCCCSCTTCSCCSSTTTTTGGGTCSCCCGGGGTCCSSCSSCSSCC CTTCCBTTBC