Back to search

Peptide record

TPDB92834

CAD-2 Cell-penetrating Peptides standard
20 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB92834
CAD-2
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD CellPPD-MOD CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP
standard
No
A 20-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD, CellPPD-MOD, CPPsite3.0, and other sources, with an available 3D structural model.
C-terminal: Amidation
Sequence
GLWRALWRLLRSLWRLLWKA-NH2
Physicochemical Analysis
C127H197N37O22
NDCEQHIMFPTYV
L
2594.20
12.88
5
0
13
+5
-7.29
0.175
146.50
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
22000
848.05
1
Residue Composition
number
2
A
4
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
7
L
1
K
0
M
0
F
0
P
1
S
0
T
4
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 7 K: 1 M: 0 F: 0 P: 0 S: 1 T: 0 W: 4 Y: 0 V: 0
Chemical Descriptors
20
C127H197N37O22
2594.20
12.88
+5
-7.29
0.175
Amidation
L
Linear
Free
N[C@@H](CCCCN)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Ht-1080 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Near-infrared fluorescent DY676 labelled cargos (BSA, monoclonal Ab)
Golgi/Late Endosomal Localization
CAD-2 resulted in high internalization levels for BSA-DY676 and Trastuzumab-DY652
In vitro
CCSSSCCSBTTTSBSSCC
Additional Detail Fields 1 fields
CCSSSCCSBTTTSBSSCC