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Peptide record

TPDB92833

CADY-K Cell-penetrating Peptides standard
19 amino acids
Basic Information
3D PDB MODEL
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TPDB92833
CADY-K
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 19-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: Nanoparticle
Sequence
GLWRALWRLLRSLWRLLWK
Physicochemical Analysis
C124H192N36O21
NDCEQHIMFPTYV
L
2523.12
12.88
5
0
12
+5
-7.12
0.089
148.95
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
22000
871.94
1
Residue Composition
number
1
A
4
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
7
L
1
K
0
M
0
F
0
P
1
S
0
T
4
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 7 K: 1 M: 0 F: 0 P: 0 S: 1 T: 0 W: 4 Y: 0 V: 0
Chemical Descriptors
19
C124H192N36O21
2523.12
12.88
+5
-7.12
0.089
Free
Nanoparticle
L
Amphipathic
Linear
Free
NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Neuro 2A-Luc+ (Firefly Luciferase) Murine Neuroblastoma And B16-F10-Luc+ Murine Melanoma Cell Lines.

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
siRNA
CADY-K:siRNA showed 2-fold higher knock-down efficiency than the CADY:siRNA.
In vitro
CTHHHHHHHHHHHHHHHCCC
Additional Detail Fields 1 fields
CTHHHHHHHHHHHHHHHCCC