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Peptide record

TPDB92822

HB-EGF Cell-penetrating Peptides standard
22 amino acids
Basic Information
3D PDB MODEL
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TPDB92822
HB-EGF
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD-MOD CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP
standard
No
A 22-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD-MOD, CPPsite3.0, MLCPP 2.0, and other sources, with an available 3D structural model.
C-terminal: Amidation
Sequence
GKRKKKGKGLGKKRDPCLRKYK-NH2
Physicochemical Analysis
C113H206N40O26S1
ANEQHIMFSTWV
K
2573.19
11.33
12
1
3
+11
10.76
-2.114
35.45
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1490
57.90
2
Residue Composition
number
0
A
3
R
0
N
1
D
1
C
0
E
0
Q
4
G
0
H
0
I
2
L
9
K
0
M
0
F
1
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 0 D: 1 C: 1 E: 0 Q: 0 G: 4 H: 0 I: 0 L: 2 K: 9 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
22
C113H206N40O26S1
2573.19
11.33
+11
10.76
-2.114
Amidation
L
Linear
NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

RAW 264.7 cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Fluorophore (FITC)
Cytosol
HBP was internalized by cells, as measured by significantly increased cytosolic fluorescence
In vitro
CCCCCSSSCCCCCCCSSSSCCC
Additional Detail Fields 1 fields
CCCCCSSSCCCCCCCSSSSCCC