Back to search

Peptide record

TPDB92817

CF-GFLG-Penetratin(desMet) Cell-penetrating Peptides standard
19 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB92817
CF-GFLG-Penetratin(desMet)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 19-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: labile spacer (GFLG) N-terminal: Conjugated with CF
Sequence
GFLGRQIKIWFQNRRKWKK
Physicochemical Analysis
C118H185N37O23
ADCEHMPSTYV
K
2490.00
12.72
7
0
7
+7
0.85
-1.253
61.58
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
11000
441.77
3
Residue Composition
number
0
A
3
R
1
N
0
D
0
C
0
E
2
Q
2
G
0
H
2
I
1
L
4
K
0
M
2
F
0
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 1 D: 0 C: 0 E: 0 Q: 2 G: 2 H: 0 I: 2 L: 1 K: 4 M: 0 F: 2 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
19
C118H185N37O23
2490.00
12.72
+7
0.85
-1.253
Free
labile spacer (GFLG)
L
Amphipathic
Linear
Conjugated with CF
NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

MCF-7 And MDA-MB-235

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
Synthetic
Pentaglutamylated derivative of Methotrexate (MTX-Glu5)
GFLG between the pentaglutamyl moiety and the penetratin(desMet) increased significantly the cellular uptake, but lower in comparison with the free penetratin(desMet).
In vitro
CCCSSCCCCCTTSCSTTCC
Additional Detail Fields 1 fields
CCCSSCCCCCTTSCSTTCC