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Peptide record

TPDB92816

MPG-iCAL36 Blood-Brain Barrier Cell-penetrating Peptides standard
27 amino acids
Basic Information
3D PDB MODEL
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TPDB92816
MPG-iCAL36
Blood-Brain Barrier Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
BBPpredict CPPsite3.0
standard
No
A 27-aa standard natural multi-activity (Blood-Brain Barrier and Cell-penetrating Peptides) peptide sequence curated from BBPpredict and CPPsite3.0, with an available 3D structural model.
Chemical: TAMRA-labelled
Sequence
GALFLGWLGAAGSTMGAWSQPKKKRKV
Physicochemical Analysis
C131H209N37O32S1
NDCEHIY
G
2846.39
11.80
5
0
12
+5
-1.10
-0.141
68.89
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
11000
386.45
4
Residue Composition
number
4
A
1
R
0
N
0
D
0
C
0
E
1
Q
5
G
0
H
0
I
3
L
4
K
1
M
1
F
1
P
2
S
1
T
2
W
0
Y
1
V
Amino Acid Distribution
A: 4 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 5 H: 0 I: 0 L: 3 K: 4 M: 1 F: 1 P: 1 S: 2 T: 1 W: 2 Y: 0 V: 1
Chemical Descriptors
27
C131H209N37O32S1
2846.39
11.80
+5
-1.10
-0.141
Free
TAMRA-labelled
L
Linear
Free
NCC(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](C)/C/1=N/CC(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CC2=CN=C(C)/C/2=C\C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)N)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)OO1
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Caco-2 And Calu-3 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
TAMRA dye and iCAL36 peptide
Cytoplasm
MPG-iCAL36 and Pen-iCAL36 seemed to be superior uptake than Tat-iCAL36 and its analogs in both cell lines.
In vitro
CCCSCSBBEEBTEESSTTBSSSTTBCC
Additional Detail Fields 1 fields
CCCSCSBBEEBTEESSTTBSSSTTBCC