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Peptide record

TPDB92814

DEN-NRTN-30 (Compound 2) Cell-penetrating Peptides standard
30 amino acids
Basic Information
3D PDB MODEL
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TPDB92814
DEN-NRTN-30 (Compound 2)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 30-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
N-terminal: poly-L-lysine dendron
Sequence
GAAEAAARVYDLGLRRLRQRRRLRRERVRA
Physicochemical Analysis
C150H268N64O39
NCHIKMFPSTW
R
3592.18
12.48
11
3
13
+8
10.72
-1.040
91.33
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1490
41.48
2
Residue Composition
number
6
A
11
R
0
N
1
D
0
C
2
E
1
Q
2
G
0
H
0
I
4
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
1
Y
2
V
Amino Acid Distribution
A: 6 R: 11 N: 0 D: 1 C: 0 E: 2 Q: 1 G: 2 H: 0 I: 0 L: 4 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 2
Chemical Descriptors
30
C150H268N64O39
3592.18
12.48
+8
10.72
-1.040
Free
L
Cationic
Linear
poly-L-lysine dendron
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
YOYO-1 labeled pDNA
Cytoplasm
Showed a significant increase (2-10 fold increase) in comparison to Compound 1
Non-endocytic mechanism
In vitro
CCCCCSCCTTCC
Additional Detail Fields 1 fields
CCCCCSCCTTCC