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Peptide record

TPDB92811

PF221 Cell-penetrating Peptides standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB92811
PF221
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 18-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation Chemical: Graphene oxide nanosheet N-terminal: Stearylation
Sequence
FLKLLKKFLFLKLLKKFL-NH2
Physicochemical Analysis
C120H198N24O19
ARNDCEQGHIMPSTWYV
L
2281.04
11.21
6
0
12
+6
-3.06
1.011
173.33
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
8
L
6
K
0
M
4
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 8 K: 6 M: 0 F: 4 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
18
C120H198N24O19
2281.04
11.21
+6
-3.06
1.011
Amidation
Graphene oxide nanosheet
L
Cationic
Linear
Stearylation
N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

U-87 Mg-Luc2, HeLa Pulc 705

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
plasmid (pGL3), splice correction oligonucleotides (SCO) or small interfering RNA (siRNA)
GO-pGL3-PF221 shows a 2.5-fold improvement compared to pGL3-PF221
In vitro
CCSTTCCC
Additional Detail Fields 1 fields
CCSTTCCC