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Peptide record

TPDB92810

G53-4 Cell-penetrating Peptides standard
23 amino acids
Basic Information
3D PDB MODEL
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TPDB92810
G53-4
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD CellPPD-MOD CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP
standard
No
A 23-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD, CellPPD-MOD, CPPsite3.0, and other sources, with an available 3D structural model.
C-terminal: Conjugated with TAMRA Chemical: Lys side chain amine at the C-terminus
Sequence
FLIFIRVICIVIAKLKANLMCKT
Physicochemical Analysis
C125H216N30O26S3
DEQGHPSWY
I
2651.46
10.32
4
0
15
+4
-2.06
1.652
169.57
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
125
4.71
4
Residue Composition
number
2
A
1
R
1
N
0
D
2
C
0
E
0
Q
0
G
0
H
5
I
3
L
3
K
1
M
2
F
0
P
0
S
1
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 2 R: 1 N: 1 D: 0 C: 2 E: 0 Q: 0 G: 0 H: 0 I: 5 L: 3 K: 3 M: 1 F: 2 P: 0 S: 0 T: 1 W: 0 Y: 0 V: 2
Chemical Descriptors
23
C125H216N30O26S3
2651.46
10.32
+4
-2.06
1.652
Conjugated with TAMRA
Lys side chain amine at the C-terminus
L
Hydrophobic
Linear
Free
N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CS)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

By-2 Cells Leaves Of Nicotiana Benthamiana, Arabidopsis Thaliana, Tomato (Solanum Lycopersicum), Poplar (Hybrid Aspen Populus Tremula×Tremuloides Line T89), And Rice (Oryza Sativa).

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Hydrophobic
TAMRA dye
G53-4 were the least efficient CPPs in BY-2 cells
In vitro
CCCSCCCTTTTGGGTSCSSCCCC
Additional Detail Fields 1 fields
CCCSCCCTTTTGGGTSCSSCCCC