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Peptide record

TPDB92804

ETWW-lipopeptide Cell-penetrating Peptides standard
4 amino acids
Basic Information
3D PDB MODEL
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TPDB92804
ETWW-lipopeptide
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 4-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
N-terminal: Palmitoylation
Sequence
ETWW
Physicochemical Analysis
C31H36N6O8
ARNDCQGHILKMFPSYV
W
620.66
3.29
0
1
2
-1
-1.54
-1.500
0.00
Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour
11000
1772.30
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
1
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
1
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 1 W: 2 Y: 0 V: 0
Chemical Descriptors
4
C31H36N6O8
620.66
3.29
-1
-1.54
-1.500
Free
L
Anionic
Linear
Palmitoylation
N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

MCF7 Cells

Assay & Model

B16F10 tumor bearing C57BL/6J female mice
B16F10 tumor bearing C57BL/6J female mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Anionic
Synthetic
Liposome encapsulated with DOX
Nucleus
ETWW significantly enhances the DOX delivery efficiency in the nucleus.
In vitro and in vivo
CCCC
Additional Detail Fields 1 fields
CCCC