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Peptide record

TPDB92800

CPP2 Cell-penetrating Peptides Tumor-homing Peptides standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB92800
CPP2
Cell-penetrating Peptides Tumor-homing Peptides
Cancer-related peptides Delivery and barrier-penetrating peptides
CellPPD CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP TumorHoPe2.0
standard
No
A 15-aa standard natural multi-activity (Cell-penetrating Peptides and Tumor-homing Peptides) peptide sequence curated from CellPPD, CPPsite3.0, MLCPP 2.0, and other sources, with an available 3D structural model.
N-terminal: Conjugated with FITC
Sequence
DSLKSYWYLQKFSWR
Physicochemical Analysis
C97H135N23O24
ANCEGHIMPTV
S
2007.28
9.97
3
1
7
+2
-2.84
-1.047
52.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
13980
696.47
6
Residue Composition
number
0
A
1
R
0
N
1
D
0
C
0
E
1
Q
0
G
0
H
0
I
2
L
2
K
0
M
1
F
0
P
3
S
0
T
2
W
2
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 1 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 0 L: 2 K: 2 M: 0 F: 1 P: 0 S: 3 T: 0 W: 2 Y: 2 V: 0
Chemical Descriptors
15
C97H135N23O24
2007.28
9.97
+2
-2.84
-1.047
Free
L
Linear
Conjugated with FITC
NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Hct116, Sw480, Lovo

Assay & Model

SW480 cells bearing 4-week-old male mice
SW480 cells bearing 4-week-old male mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
FITC dye
CPP2 a higher MFI and positive rate than both R8 and TAT
In vitro and in vivo
CHHHHHHHHHTTTSCC
Additional Detail Fields 1 fields
CHHHHHHHHHTTTSCC