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Peptide record

TPDB92798

NLS Cell-penetrating Peptides standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB92798
NLS
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 17-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: PHBV nanoparticles
Sequence
DRQIKIWFQNRRMKWKK
Physicochemical Analysis
C108H173N35O23S1
ACEGHLPSTYV
K
2361.84
12.16
7
1
6
+6
3.52
-1.835
45.88
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
11000
465.74
3
Residue Composition
number
0
A
3
R
1
N
1
D
0
C
0
E
2
Q
0
G
0
H
2
I
0
L
4
K
1
M
1
F
0
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 1 D: 1 C: 0 E: 0 Q: 2 G: 0 H: 0 I: 2 L: 0 K: 4 M: 1 F: 1 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
17
C108H173N35O23S1
2361.84
12.16
+6
3.52
-1.835
Free
PHBV nanoparticles
L
Linear
Free
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Saos-2 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Non-natural residues Linear L
Doxorubicin (DOX)
Nucleus
Saos-2 cells treated with NP-DOX-NLS showed that the nanoparticles successfully crossed the plasma membrane and accumulated around the nucleus
In vitro