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Peptide record

TPDB92797

DK17W Cell-penetrating Peptides standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB92797
DK17W
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 17-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation
Sequence
DRQIKIWFQNRRMKWKK-NH2
Physicochemical Analysis
C108H173N35O23S1
ACEGHLPSTYV
K
2361.84
12.16
7
1
6
+6
3.52
-1.835
45.88
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
11000
465.74
3
Residue Composition
number
0
A
3
R
1
N
1
D
0
C
0
E
2
Q
0
G
0
H
2
I
0
L
4
K
1
M
1
F
0
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 1 D: 1 C: 0 E: 0 Q: 2 G: 0 H: 0 I: 2 L: 0 K: 4 M: 1 F: 1 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
17
C108H173N35O23S1
2361.84
12.16
+6
3.52
-1.835
Amidation
L
Cationic
Linear
Free
N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Assay & Model

Female SJL/Jmice (5-6 week old)
Female SJL/Jmice (5-6 week old)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Protein derived
Alexa Fluor 680 (AF680) near-infrared fluorescent dye
Infrared signals were detected on areas of the brain and the spinal cord in mice
In vivo
CCSSSCCTTTSCCCCCC
Additional Detail Fields 1 fields
CCSSSCCTTTSCCCCCC