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Peptide record

TPDB92795

cTAT Cell-penetrating Peptides standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB92795
cTAT
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 13-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Addition of Cysteine N-terminal: Cysteine And N- Terminal His-Tag
Sequence
CYGRKKRRQRRRC
Physicochemical Analysis
C70H128N34O16S2
ANDEHILMFPSTWV
R
1766.12
12.12
8
0
1
+8
6.01
-2.692
0.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
1615
91.44
4
Residue Composition
number
0
A
6
R
0
N
0
D
2
C
0
E
1
Q
1
G
0
H
0
I
0
L
2
K
0
M
0
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 2 E: 0 Q: 1 G: 1 H: 0 I: 0 L: 0 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
13
C70H128N34O16S2
1766.12
12.12
+8
6.01
-2.692
Addition of Cysteine
L
Cyclic
Cysteine And N- Terminal His-Tag
N[C@@H](CS)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CS)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa, HEK, 10T1/2, HEPG2 cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Cyclic L
Synthetic
Superfolder Green fluorescent protein (sfGFP)
Cytosol
All cell types showed an increase in uptake in response to cyclisation with HeLa producing the largest response with a 5.9-fold increase in fluorescence of TAT
Endocytosis
In vitro
CCTTTGGGSSSCC
Additional Detail Fields 1 fields
CCTTTGGGSSSCC