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Peptide record

TPDB92791

TAT Cell-penetrating Peptides standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB92791
TAT
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0 Peptipedia
standard
No
A 12-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0 and Peptipedia, with an available 3D structural model.
Chemical: Gold nanoparticles N-terminal: Addition of Cysteine
Sequence
CYGRKKRRQRRR
Physicochemical Analysis
C67H123N33O15S1
ANDEHILMFPSTWV
R
1662.99
12.41
8
0
1
+8
6.25
-3.125
0.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
1490
89.60
3
Residue Composition
number
0
A
6
R
0
N
0
D
1
C
0
E
1
Q
1
G
0
H
0
I
0
L
2
K
0
M
0
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 1 E: 0 Q: 1 G: 1 H: 0 I: 0 L: 0 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
12
C67H123N33O15S1
1662.99
12.41
+8
6.25
-3.125
Free
Gold nanoparticles
L
Cationic
Linear
Addition of Cysteine
N[C@@H](Cc1ccccc1)C(=O)/N=C/C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

MCF-7, B16F10 And Sk-Br-3 Cells

Assay & Model

Female BALB/c nude mice (6−8 weeks, 18−22 g)
Female BALB/c nude mice (6−8 weeks, 18−22 g)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Protein derived
Cy5-labeled KLAK peptide with cis-aconitic anhydride (CAA)
Lysosomes
At pH 6.5, however, a strong red signal was colocalized with lysosomes (green signal), thus indicating that PT-K-CAA possesses a higher internalization capacity than at pH 7.4
Endocytosis
In-vitro, in-vivo and ex vivo
CCTTSSCCCCC
Additional Detail Fields 1 fields
CCTTSSCCCCC