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Peptide record

TPDB92789

HIV-TAT Cell-penetrating Peptides standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB92789
HIV-TAT
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0 Peptipedia
standard
No
A 12-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0 and Peptipedia, with an available 3D structural model.
Chemical: CAAKA spacer N-terminal: Addition of Cysteine
Sequence
CYGRKKRRQRRR
Physicochemical Analysis
C67H123N33O15S1
ANDEHILMFPSTWV
R
1662.99
12.41
8
0
1
+8
6.25
-3.125
0.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
1490
89.60
3
Residue Composition
number
0
A
6
R
0
N
0
D
1
C
0
E
1
Q
1
G
0
H
0
I
0
L
2
K
0
M
0
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 1 E: 0 Q: 1 G: 1 H: 0 I: 0 L: 0 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
12
C67H123N33O15S1
1662.99
12.41
+8
6.25
-3.125
Free
CAAKA spacer
L
Cationic
Linear
Addition of Cysteine
NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCC(=O)N)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Drug Resistant Melanoma (A375 And A375-R), Mesothelioma (Msto And Msto-R), And Glioma (Rat 9L And 9L-R, And Human U87 And Ln18) Cell Lines

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Protein derived
Photoluminescent multi-shelled quantum dot (QD)
Cytoplasm and Endosomes
HIV-TAT and HIV-gp41 showing the highest punctate percentages in 9L and 9L-R
In vitro
CCHHHHHHHTTSCHHHHTTTTTTSCC
Additional Detail Fields 1 fields
CCHHHHHHHTTSCHHHHTTTTTTSCC