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Peptide record

TPDB92786

LMWP Cell-penetrating Peptides standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB92786
LMWP
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0 Peptipedia
standard
No
A 15-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0 and Peptipedia, with an available 3D structural model.
Chemical: Albumin nanoparticles
Sequence
CVSRRRRRRGGRRRR
Physicochemical Analysis
C75H147N45O17S1
ANDEQHILKMFPTWY
R
1983.34
13.00
10
0
1
+10
8.08
-2.660
19.33
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
2
Residue Composition
number
0
A
10
R
0
N
0
D
1
C
0
E
0
Q
2
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
1
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 10 N: 0 D: 0 C: 1 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
15
C75H147N45O17S1
1983.34
13.00
+10
8.08
-2.660
Free
Albumin nanoparticles
L
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

bEnd.3 And U87 Cells.

Assay & Model

Balb/c nude mice (3−4 weeks old)
Balb/c nude mice (3−4 weeks old)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
Paclitaxel (PTX) and fenretinide (4-HPR).
The uptake of L-BSA-NP by U87 cells across the bEnd.3 monolayer cells were 2.5-fold higher than with BSA-NP, demonstrating the ability of LMWP to enhance the permeation of the NPs through the bEnd.3 monolayer and uptake by the U87 cells.
In vitro and in vivo
CCCSSSTTCCCTTTTC
Additional Detail Fields 1 fields
CCCSSSTTCCCTTTTC