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Peptide record

TPDB92780

C105Y-TMR Cell-penetrating Peptides standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB92780
C105Y-TMR
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD-MOD CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP
standard
No
A 17-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD-MOD, CPPsite3.0, MLCPP 2.0, and other sources, with an available 3D structural model.
C-terminal: Amidation Chemical: Mesoporous silica nanoparticles (MSNPs
Sequence
CSIPPEVKFNKPFVYLI-NH2
Physicochemical Analysis
C97H148N20O23S1
ARDQGHMTW
P
1994.42
8.86
2
1
8
+1
1.42
0.447
102.94
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
1490
74.71
4
Residue Composition
number
0
A
0
R
1
N
0
D
1
C
1
E
0
Q
0
G
0
H
2
I
1
L
2
K
0
M
2
F
3
P
1
S
0
T
0
W
1
Y
2
V
Amino Acid Distribution
A: 0 R: 0 N: 1 D: 0 C: 1 E: 1 Q: 0 G: 0 H: 0 I: 2 L: 1 K: 2 M: 0 F: 2 P: 3 S: 1 T: 0 W: 0 Y: 1 V: 2
Chemical Descriptors
17
C97H148N20O23S1
1994.42
8.86
+1
1.42
0.447
Amidation
Mesoporous silica nanoparticles (MSNPs
L
Cationic
Linear
Free
N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)N)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Boar Sperm

Source & Reference

CPPsite3.0
CPPsite3
PCT/GB13/053394

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
Tetramethylrhodamine (TMR) labelled
Cytosol
Four fold increase in affinity toward gametes
In vitro
CCCCSCCCSCSSSCSSSCC
Additional Detail Fields 1 fields
CCCCSCCCSCSSSCSSSCC