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Peptide record

TPDB92778

Cys-R10 (CPP 2) Cell-penetrating Peptides standard
11 amino acids
Basic Information
3D PDB MODEL
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TPDB92778
Cys-R10 (CPP 2)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 11-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation N-terminal: Addition of Cysteine
Sequence
CRRRRRRRRRR-NH2
Physicochemical Analysis
C63H127N41O12S1
ANDEQGHILKMFPSTWYV
R
1683.03
13.00
10
0
0
+10
7.86
-3.864
0.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
0
A
10
R
0
N
0
D
1
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 10 N: 0 D: 0 C: 1 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
11
C63H127N41O12S1
1683.03
13.00
+10
7.86
-3.864
Amidation
L
Cationic
Linear
Addition of Cysteine
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa Kyoto Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
NLS-mCherry
Nucleolar
Efficient nucleolar delivery of 5 μM NLS-mCherry linked to a linear R10 peptide (conjugate II)
Endocytosis and transduction
In vitro
CCCCCSCCCC
Additional Detail Fields 1 fields
CCCCCSCCCC