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Peptide record

TPDB92777

B-mR9 Cell-penetrating Peptides standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB92777
B-mR9
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 21-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: FITC-labeled HA-coated nanoparticles
Sequence
CRRRRRRRRRCRRRRRRRRRC
Physicochemical Analysis
C117H233N75O22S3
ANDEQGHILKMFPSTWYV
R
3138.81
12.94
18
0
0
+18
13.86
-3.500
0.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
125
3.98
3
Residue Composition
number
0
A
18
R
0
N
0
D
3
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 18 N: 0 D: 0 C: 3 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
21
C117H233N75O22S3
3138.81
12.94
+18
13.86
-3.500
Free
FITC-labeled HA-coated nanoparticles
L
Cationic
Branched
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Nci-H460 (Cd44-Positive), MCF-7 (Cd44-Low), And Nih-3T3 (Cd44-Negative) Cells

Assay & Model

BALB/c nude mice (6 weeks old, female)
BALB/c nude mice (6 weeks old, female)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Branched L Cationic
Synthetic
Methotrexate (MTX)
Cytosol
In the NCI-H460 cells, the HA-coated B-mR9 had the highest delivery efficacy into the cytosol, indicating that B-mR9 has an outstanding MTX delivery capability. while in MCF-7 cells, the green fluorescence of the cells treated with all the particles was reduced significantly and was hardly observed in the NIH-3T3 cells.
In vitro and in vivo
CCCCCCCCSCSCSCC
Additional Detail Fields 1 fields
CCCCCCCCSCSCSCC