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Peptide record

TPDB92767

MGPE-9 Cell-penetrating Peptides standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB92767
MGPE-9
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP
standard
No
A 20-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, MLCPP 2.0, Peptipedia, and other sources, with an available 3D structural model.
Chemical: Polyplexes
Sequence
CRRLRHLRHHYRRRWHRFRC
Physicochemical Analysis
C125H198N56O22S2
ANDEQGIKMPSTV
R
2901.43
12.50
13
0
5
+9
5.61
-2.005
39.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
7115
245.22
3
Residue Composition
number
0
A
9
R
0
N
0
D
2
C
0
E
0
Q
0
G
4
H
0
I
2
L
0
K
0
M
1
F
0
P
0
S
0
T
1
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 9 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 0 H: 4 I: 0 L: 2 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 1 Y: 1 V: 0
Chemical Descriptors
20
C125H198N56O22S2
2901.43
12.50
+9
5.61
-2.005
Free
Polyplexes
L
Amphipathic
Linear
Free
N[C@@H](CS)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CS)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Dividing And Differentiated ARPE-19 And Differentiated Hfrpe Cells.

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
pFB-Gluc and pEGFP-C2 GAPDH siRNA
Nucleus
Experiments with Gaussia luciferase reporter gene clearly showed that cationic peptides achieved 10–100 fold greater transgene expression than amphipathic peptides in all studied cell types. CS coating of the peptide-based polyplexes improved transfection efficiency in both dividing ARPE-19 cells by 10 times and by five times in the corresponding differentiated cells
In vitro
CCCCSSCSSCC
Additional Detail Fields 1 fields
CCCCSSCSSCC