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Peptide record

TPDB92762

Cys-Pen (9a) Cys-penetratin Cell-penetrating Peptides standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB92762
Cys-Pen (9a) Cys-penetratin
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD CellPPD-MOD CPPsite3.0 Peptipedia PerseuCPP
standard
No
A 17-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD, CellPPD-MOD, CPPsite3.0, and other sources, with an available 3D structural model.
N-terminal: Addition of Cysteine
Sequence
CRQIKIWFQNRRMKWKK
Physicochemical Analysis
C107H173N35O21S2
ADEGHLPSTYV
K
2349.89
12.16
7
0
6
+7
2.05
-1.482
45.88
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
11000
468.11
4
Residue Composition
number
0
A
3
R
1
N
0
D
1
C
0
E
2
Q
0
G
0
H
2
I
0
L
4
K
1
M
1
F
0
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 1 D: 0 C: 1 E: 0 Q: 2 G: 0 H: 0 I: 2 L: 0 K: 4 M: 1 F: 1 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
17
C107H173N35O21S2
2349.89
12.16
+7
2.05
-1.482
Free
L
Cationic Amphipathic
Linear
Addition of Cysteine
N[C@@H](CS)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O N[C@@H](CCC(=O)N)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 2 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Tr146 Cell Line And Porcine Buccal Tissues.

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Protein derived
Alexa 647-sCT(Salmon Calcitonin)-incorporated liposomes
sCT penetrating the cells from the penetratin-conjugated liposomes was 1.93 times higher compared to the control liposomes and 5.8 times higher than that of the free sCT solution
In vitro and ex vivo
CCSCCCCSSTTCSCCCC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

Mkn-28, Caco-2 , Ht-29

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Amphipathic
Gemcitabine
In vitro
CCSCSSSCC
Additional Detail Fields 1 fields
CCSCCCCSSTTCSCCCC CCSCSSSCC