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Peptide record

TPDB92755

RKO-R5-1 Cell-penetrating Peptides Tumor-homing Peptides standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB92755
RKO-R5-1
Cell-penetrating Peptides Tumor-homing Peptides
Cancer-related peptides Delivery and barrier-penetrating peptides
CPPsite3.0 TumorHoPe2.0
standard
No
A 9-aa standard natural multi-activity (Cell-penetrating Peptides and Tumor-homing Peptides) peptide sequence curated from CPPsite3.0 and TumorHoPe2.0, with an available 3D structural model.
C-terminal: Addition of Cysteine N-terminal: Addition of Cysteine
Sequence
CPKSNNGVC
Physicochemical Analysis
C35H60N12O13S2
ARDEQHILMFTWY
NC
921.05
8.29
1
0
1
+1
2.01
-0.500
32.22
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
125
13.57
5
Residue Composition
number
0
A
0
R
2
N
0
D
2
C
0
E
0
Q
1
G
0
H
0
I
0
L
1
K
0
M
0
F
1
P
1
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 2 D: 0 C: 2 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 1 M: 0 F: 0 P: 1 S: 1 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
9
C35H60N12O13S2
921.05
8.29
+1
2.01
-0.500
Addition of Cysteine
L
Linear
Addition of Cysteine
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Rko, Ccd-841-Con, Caco-2, Hct 116 And Hct-15 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Phage Display
FAM label (FAM-RKOpep) at the N-terminus.
About 90% of the overall RKO cell population was bound by the RKOpep and 56.69±6.8%, 43.29±10.78% and 42.13±4.08% of the overall Caco-2, HCT 116 and HCT-15 cell population was bound to the RKOpep, respectively. while for CCD-841-CoN, almost no positive signal was detected independently of the peptide concentration,
In vitro
CCCSGGGGGSSCCCCCC
Additional Detail Fields 1 fields
CCCSGGGGGSSCCCCCC