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Peptide record

TPDB92753

Cell-penetrating Peptides Tumor-homing Peptides standard
5 amino acids
Basic Information
3D PDB MODEL
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TPDB92753
Cell-penetrating Peptides Tumor-homing Peptides
Cancer-related peptides Delivery and barrier-penetrating peptides
CPPsite3.0 Peptipedia PerseuCPP TumorHoPe2.0
standard
No
A 5-aa standard natural multi-activity (Cell-penetrating Peptides and Tumor-homing Peptides) peptide sequence curated from CPPsite3.0, Peptipedia, PerseuCPP, and other sources, with an available 3D structural model.
N-terminal: fluorescein isothiocyanate (FITC)/ FPR675 near-infrared fluorescence (NIRF)
Sequence
CNGRC
Physicochemical Analysis
C18H33N9O7S2
ADEQHILKMFPSTWYV
C
551.64
8.30
1
0
0
+1
0.76
-0.680
0.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
125
22.66
3
Residue Composition
number
0
A
1
R
1
N
0
D
2
C
0
E
0
Q
1
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 1 D: 0 C: 2 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
5
C18H33N9O7S2
551.64
8.30
+1
0.76
-0.680
fluorescein isothiocyanate (FITC)/ FPR675 near-infrared fluorescence (NIRF)
Evidence Records 1 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell, Endothelial cell
Homing
Bladder cancer
aminopeptidase N

Source & Reference

TumorHoPe2.0
TumorHoPe2
Bladder tumor-targeted delivery of pro-apoptotic peptide for cancer therapy
2016
Hyun-Kyung Jung et al. J Control Release. 2016 Aug 10:235:259-267.

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
HT1376(human bladder tumor) cell line, BEAS-2B (normal bronchial epithelial cells), Jurkat (human T lymphocytes) cell line, HUVECs (human umbilical vein endothelial cells), JEG-3 and BeWo (human trophoblastic cells)
5-week-old BALB/c nu/nu male mice
Phage Display library
D-KLAKLAKKLAKLAK (KLA) peptide
cyclic
Additional Detail Fields 3 fields
D-KLAKLAKKLAKLAK (KLA) peptide
HT1376(human bladder tumor) cell line, BEAS-2B (normal bronchial epithelial cells), Jurkat (human T lymphocytes) cell line, HUVECs (human umbilical vein endothelial cells), JEG-3 and BeWo (human trophoblastic cells)
5-week-old BALB/c nu/nu male mice