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Peptide record

TPDB92749

KAibA Cell-penetrating Peptides modified_plain modified
10 amino acids
Basic Information
3D PDB MODEL
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TPDB92749
KAibA
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
modified_plain
Yes
A 10-aa modified cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation Chemical: X= 2-aminoisobutyric acid, MAL-TEG-(KH)14 micelles N-terminal: Acetylation
Sequence
Ac-CKXAKXAKXA-NH2
Physicochemical Analysis
C30H58N10O8S1
RNDEQGHILMFPSTWYV
AK
718.91
10.32
3
0
3
+3
2.22
-0.380
30.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
3
A
0
R
0
N
0
D
1
C
0
E
0
Q
0
G
0
H
0
I
0
L
3
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 3 R: 0 N: 0 D: 0 C: 1 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 3 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
10
C30H58N10O8S1
718.91
10.32
+3
2.22
-0.380
Amidation
X= 2-aminoisobutyric acid, MAL-TEG-(KH)14 micelles
Modified
Linear
Acetylation
N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

A. Thaliana Cotyledons

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear Modified
Synthetic
Cy3-pDNA (p35S-Nluc-tNOS)
Vacuole, Cytosol And Protoplast
KAibA-MC was significantly more effective than Tat-MC in transfection. KAibA/EED4-MC and KAibA/LAH4-L1-MC had higher uptake efficiency than KAibA/GALA-MC but all exhibited lower efficiency than the CPP-modified micelle (KAibA-MC).while KAibA/EED4-MC and KAibA/LAH4-L1-MC exhibited significantly higher transfection efficiency than KAibA-MC, while KAibA/GALA-MC demonstrated comparable efficiency to a control (naked pDNA)
Endocytosis
In vitro
CGGGGGGTGGGC
Additional Detail Fields 1 fields
CGGGGGGTGGGC