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Peptide record

TPDB92749

KAibA Cell-penetrating Peptides modified_plain modified
10 source-reported length (unverified)
Basic Information
TPDB92749
KAibA
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
modified_plain
Yes
A modified cell-penetrating peptides peptide record curated from CPPsite3.0, without an available 3D structural model. Source-reported length: 10 (unverified).
C-terminal: Amidation Chemical: X= 2-aminoisobutyric acid, MAL-TEG-(KH)14 micelles N-terminal: Acetylation
Sequence
Ac-CKXAKXAKXA-NH2

Source notation is retained verbatim; residue notation and chemical identity have not been independently validated. The displayed length is source-reported and unverified.

Physicochemical Analysis

Sequence-only estimates are not provided for modified or non-standard source notation. Reported molecular properties, when available, are retained below with their source records.

Chemical Descriptors
10 source-reported length (unverified)
Amidation Activity
X= 2-aminoisobutyric acid, MAL-TEG-(KH)14 micelles Activity
Modified Activity
Linear Activity
Acetylation Activity
N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)O Activity
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

A. Thaliana Cotyledons

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear Modified
Synthetic
Cy3-pDNA (p35S-Nluc-tNOS)
Vacuole, Cytosol And Protoplast
KAibA-MC was significantly more effective than Tat-MC in transfection. KAibA/EED4-MC and KAibA/LAH4-L1-MC had higher uptake efficiency than KAibA/GALA-MC but all exhibited lower efficiency than the CPP-modified micelle (KAibA-MC).while KAibA/EED4-MC and KAibA/LAH4-L1-MC exhibited significantly higher transfection efficiency than KAibA-MC, while KAibA/GALA-MC demonstrated comparable efficiency to a control (naked pDNA)
Endocytosis
In vitro
CGGGGGGTGGGC
Additional Detail Fields 1 fields
CGGGGGGTGGGC