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Peptide record

TPDB92746

CPP (Penetratin-derived) Cell-penetrating Peptides standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB92746
CPP (Penetratin-derived)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 9-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: YSA peptide conjugated Nanobubbles (NBs)
Sequence
CKRRMKWKK
Physicochemical Analysis
C55H98N20O10S2
ANDEQGHILFPSTYV
K
1263.63
11.63
6
0
2
+6
3.26
-2.344
0.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
5500
435.25
1
Residue Composition
number
0
A
2
R
0
N
0
D
1
C
0
E
0
Q
0
G
0
H
0
I
0
L
4
K
1
M
0
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 1 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 4 M: 1 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
9
C55H98N20O10S2
1263.63
11.63
+6
3.26
-2.344
Free
YSA peptide conjugated Nanobubbles (NBs)
L
Linear
Free
N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

MCF-7 Cells

Assay & Model

Female BALB/c nude mice (weighing 18–22 g, 5 week old)
Female BALB/c nude mice (weighing 18–22 g, 5 week old)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
FAM-labeled Anti-c-Myc siRNA
Cytoplasm
Order of cellular uptake of CPP–siRNA/YSA-NB(+US) > CPP–siRNA/N-NB (+US) > CPP–siRNA/YSA-NB > CPP–siRNA/N-NB.
In vitro and in vivo
CCCCSSCCC
Additional Detail Fields 1 fields
CCCCSSCCC