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Peptide record

TPDB92740

F3 Cell-penetrating Peptides Tumor-homing Peptides standard
32 amino acids
Basic Information
3D PDB MODEL
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TPDB92740
F3
Cell-penetrating Peptides Tumor-homing Peptides
Cancer-related peptides Delivery and barrier-penetrating peptides
CPPsite3.0 Peptipedia PerseuCPP TumorHoPe2.0
standard
No
A 32-aa standard natural multi-activity (Cell-penetrating Peptides and Tumor-homing Peptides) peptide sequence curated from CPPsite3.0, Peptipedia, PerseuCPP, and other sources, with an available 3D structural model.
C-terminal: Amidation Chemical: DART nanoparticles
Sequence
CKDEPQRRSARLSAKPAPPKPEPKPKKAPAKK-NH2
Physicochemical Analysis
C155H268N50O42S1
NGHIMFTWYV
KP
3536.20
10.96
11
3
6
+8
18.41
-1.806
27.81
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
4
Residue Composition
number
5
A
3
R
0
N
1
D
1
C
2
E
1
Q
0
G
0
H
0
I
1
L
8
K
0
M
0
F
8
P
2
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 5 R: 3 N: 0 D: 1 C: 1 E: 2 Q: 1 G: 0 H: 0 I: 0 L: 1 K: 8 M: 0 F: 0 P: 8 S: 2 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
32
C155H268N50O42S1
3536.20
10.96
+8
18.41
-1.806
Amidation
DART nanoparticles
L
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

MDA-MB-231 Cells And HUVEC Cells

Assay & Model

Female nude Balb/c mice (18–20 g)
Female nude Balb/c mice (18–20 g)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
CF peptide
Breast cancer cells and the HUVEC cells treated by CF-NP-C6 (pH 6.0) achieving the strongest fluorescent intensity.
In vitro and in vivo
CCCCCCC
Additional Detail Fields 1 fields
CCCCCCC