Back to search

Peptide record

TPDB92739

CH2 R4 H2 C STR-CH2R4H2C Cell-penetrating Peptides modified_plain modified
10 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

Standard-residue backbone model; source-recorded chemical modifications are not verified in these coordinates.

TPDB92739
CH2 R4 H2 C STR-CH2R4H2C
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD-MOD CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP
modified_plain
Yes
A 10-aa modified cell-penetrating peptides peptide sequence curated from CellPPD-MOD, CPPsite3.0, MLCPP 2.0, and other sources, with an available 3D structural model.
N-terminal: Stearylation
Sequence
CHHRRRRHHC
Physicochemical Analysis

Sequence-only estimates are not provided for modified or non-standard source notation. Reported molecular properties, when available, are retained below with their source records.

Chemical Descriptors
10 reviewed residue count
Free Activity
L Activity
Cyclic Linear Activity
Stearylation Activity
N[C@@H](CS)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CS)C(=O)O N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCN=C)C(=O)O Activity
Evidence Records 2 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

S-180 sarcoma cells

Assay & Model

ICR male mice
ICR male mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Cyclic L
Synthetic
Nucleic aciud (siRNA)
Cytoplasm
The cellular uptake ability of the carrier/FAM-siRNA complexes with fetal bovine serum was significantly higher than that of naked FAM-siRNA
In vitro and in vivo
CCCCCC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Assay & Model

Six-week-old male ICR mice and NC/Nga mice
Six-week-old male ICR mice and NC/Nga mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Synthetic
FAM-labeled siRNA
STR-CH2R4H2C and AT1002 treatment showed the strongest fluorescence
In vivo
CCSSCSSCCCCCCCC
Additional Detail Fields 1 fields
CCCCCC CCSSCSSCCCCCCCC