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Peptide record

TPDB92739

CH2 R4 H2 C STR-CH2R4H2C Cell-penetrating Peptides standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB92739
CH2 R4 H2 C STR-CH2R4H2C
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD-MOD CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP
standard
No
A 10-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD-MOD, CPPsite3.0, MLCPP 2.0, and other sources, with an available 3D structural model.
N-terminal: Stearylation
Sequence
CHHRRRRHHC
Physicochemical Analysis
C54H88N30O11S2
ANDEQGILKMFPSTWYV
RH
1397.61
11.93
8
0
0
+4
6.60
-2.580
0.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
125
8.94
2
Residue Composition
number
0
A
4
R
0
N
0
D
2
C
0
E
0
Q
0
G
4
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 4 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 0 H: 4 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
10
C54H88N30O11S2
1397.61
11.93
+4
6.60
-2.580
Free
L
Cyclic Linear
Stearylation
N[C@@H](CS)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CS)C(=O)O N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 2 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

S-180 sarcoma cells

Assay & Model

ICR male mice
ICR male mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Cyclic L
Synthetic
Nucleic aciud (siRNA)
Cytoplasm
The cellular uptake ability of the carrier/FAM-siRNA complexes with fetal bovine serum was significantly higher than that of naked FAM-siRNA
In vitro and in vivo
CCCCCC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Assay & Model

Six-week-old male ICR mice and NC/Nga mice
Six-week-old male ICR mice and NC/Nga mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Synthetic
FAM-labeled siRNA
STR-CH2R4H2C and AT1002 treatment showed the strongest fluorescence
In vivo
CCSSCSSCCCCCCCC
Additional Detail Fields 1 fields
CCCCCC CCSSCSSCCCCCCCC