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Peptide record

TPDB92738

Pep4(CHAT) Cell-penetrating Peptides standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB92738
Pep4(CHAT)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 15-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: Nanoparticles
Sequence
CHHHRRRWRRRHHHC
Physicochemical Analysis
C89H136N46O16S2
ANDEQGILKMFPSTYV
RH
2170.48
12.40
12
0
1
+6
8.29
-2.807
0.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
5625
259.16
2
Residue Composition
number
0
A
6
R
0
N
0
D
2
C
0
E
0
Q
0
G
6
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 0 H: 6 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
15
C89H136N46O16S2
2170.48
12.40
+6
8.29
-2.807
Free
Nanoparticles
L
Cationic
Linear
Free
N[C@@H](CS)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CS)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

MCF-7 And MDA-MB-231 Cells And Pc-3 And Du145 Cells

Assay & Model

BALB/c SCID mice
BALB/c SCID mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
pEGFP-N1 and Cy3-labelled pLuc
Cytoplasm and nucleus
Pep4, at N:P 12 resulted in 30% and 23% transfection in MCF-7 and MDA-MB-231 cells respectively similar to RALA (30% in MCF-7 and 27% in MDA-MB-231)
Endocytosis
In vitro and in vivo
CCSSCSCCC
Additional Detail Fields 1 fields
CCSSCSCCC