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Peptide record

TPDB92737

HR9 Cell-penetrating Peptides standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB92737
HR9
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0 MLCPP 2.0 Peptipedia
standard
No
A 21-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, MLCPP 2.0, and Peptipedia, with an available 3D structural model.
N-terminal: Conjugated with FITC
Sequence
CHHHHHRRRRRRRRRHHHHHC
Physicochemical Analysis
C120H190N68O22S2
ANDEQGILKMFPSTWYV
H
3001.39
12.70
19
0
0
+10
16.41
-3.214
0.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
125
4.16
2
Residue Composition
number
0
A
9
R
0
N
0
D
2
C
0
E
0
Q
0
G
10
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 9 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 0 H: 10 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
21
C120H190N68O22S2
3001.39
12.70
+10
16.41
-3.214
Free
L
Cationic
Linear
Conjugated with FITC
N[C@@H](CS)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CS)C(=O)O
Evidence Records 2 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

A549 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
FITC dye
HR9-FITC were internalized at low concentrations (< 1μM)
In vitro
CCHHHHGGGCC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

A549 And HeLa Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Non-natural residues Linear L Cationic
Protein derived
FITC dye
Consistently higher than FITC-L6
Direct membrane penetration
In vitro
Additional Detail Fields 1 fields
CCHHHHGGGCC