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Peptide record

TPDB92736

HR-9 Cell-penetrating Peptides standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB92736
HR-9
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0 MLCPP 2.0 Peptipedia
standard
No
A 21-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, MLCPP 2.0, and Peptipedia, with an available 3D structural model.
Chemical: Nanoparticles
Sequence
CHHHHHRRRRRRRRRHHHHHC
Physicochemical Analysis
C120H190N68O22S2
ANDEQGILKMFPSTWYV
H
3001.39
12.70
19
0
0
+10
16.41
-3.214
0.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
125
4.16
2
Residue Composition
number
0
A
9
R
0
N
0
D
2
C
0
E
0
Q
0
G
10
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 9 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 0 H: 10 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
21
C120H190N68O22S2
3001.39
12.70
+10
16.41
-3.214
Free
Nanoparticles
L
Cationic
Linear
Free
N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)O
Evidence Records 2 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Hek-293T Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
pEGFP-N1-nef-vif-gp160-p24
HR9 peptides could deliver effectively pEGFP-nef-vif-gp160-p24(54.95%)
In vitro
CGGGBCCSSSSCBCTTCCCSSCCCCC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

Hek-293T Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic
Synthetic
pEGFP-N1-nef-vpu-gp160-p24
HR9 peptides could deliver effectively pEGFP-nef-vpu-gp160-p24(25.11%)
In vitro
CGGGBCCSSSSCBCTTCCCSSCCCCC
Additional Detail Fields 1 fields
CGGGBCCSSSSCBCTTCCCSSCCCCC