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Peptide record

TPDB92735

RACPP (C(HE)10G5R6 ) Cell-penetrating Peptides standard
32 amino acids
Basic Information
3D PDB MODEL
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TPDB92735
RACPP (C(HE)10G5R6 )
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 32-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: Coumarin 6-labelled polymer micelles
Sequence
CHEHEHEHEHEHEHEHEHEHEGGGGGRRRRRR
Physicochemical Analysis
C159H234N70O53S1
ANDQILKMFPSTWYV
EH
4006.10
6.20
16
10
0
-3
34.47
-2.922
0.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
0
A
6
R
0
N
0
D
1
C
10
E
0
Q
5
G
10
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 1 E: 10 Q: 0 G: 5 H: 10 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
32
C159H234N70O53S1
4006.10
6.20
-3
34.47
-2.922
Free
Coumarin 6-labelled polymer micelles
L
Cationic
Linear
Free
N[C@@H](CS)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

4T1 Cells

Assay & Model

4T1-BALB/c tumor xenograft model
4T1-BALB/c tumor xenograft model

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
Paclitaxel (PTX)
Cytoplasm and Endosomes/Lysosomes
Internalization is ~3-fold higher at pH 6.0 than at pH 7.5
Energy-dependent and clathrin-mediated endocytosis
In vitro and in vivo
CCCSSSSSCSSSCCCC
Additional Detail Fields 1 fields
CCCSSSSSCSSSCCCC