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Peptide record

TPDB92731

FAM-CGY Blood-Brain Barrier Cell-penetrating Peptides standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB92731
FAM-CGY
Blood-Brain Barrier Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
BBPpredict CPPsite3.0
standard
No
A 16-aa standard natural multi-activity (Blood-Brain Barrier and Cell-penetrating Peptides) peptide sequence curated from BBPpredict and CPPsite3.0, with an available 3D structural model.
Chemical: NanoLigand Carriers (NLCs) , nanofibres
Sequence
CGYRPVHNIRGHWAPG
Physicochemical Analysis
C81H118N28O19S1
DEQLKMFST
G
1820.06
9.90
4
0
5
+2
1.45
-0.781
48.75
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
6990
384.05
3
Residue Composition
number
1
A
2
R
1
N
0
D
1
C
0
E
0
Q
3
G
2
H
1
I
0
L
0
K
0
M
0
F
2
P
0
S
0
T
1
W
1
Y
1
V
Amino Acid Distribution
A: 1 R: 2 N: 1 D: 0 C: 1 E: 0 Q: 0 G: 3 H: 2 I: 1 L: 0 K: 0 M: 0 F: 0 P: 2 S: 0 T: 0 W: 1 Y: 1 V: 1
Chemical Descriptors
16
C81H118N28O19S1
1820.06
9.90
+2
1.45
-0.781
Free
NanoLigand Carriers (NLCs) , nanofibres
L
Amphiphilic
Linear
Free
NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

hCMEC/D3 Cells, MCF-7 Cells , Ebm-2 And MCF-10A Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphiphilic
Protein derived
5-FAM at N terminal
Early Endosomes And Lysosomal Compartments
In contrast to FAM-CGY, the cellular uptake of FAM-GYR and other modified/scrambled FAM-conjugated peptides was relatively low.
Clathrin- and Caveolae-dependent endocytosis and macropinocytosis
In vitro
CCCSSSSCCSCCC
Additional Detail Fields 1 fields
CCCSSSSCCSCCC