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Peptide record

TPDB92729

CG-TAT-GC Cell-penetrating Peptides standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB92729
CG-TAT-GC
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0 Peptipedia PerseuCPP
standard
No
A 15-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, Peptipedia, and PerseuCPP, with an available 3D structural model.
C-terminal: Addition of dipeptide GC Chemical: Hyaluronic acid (HA) conjugated nanoparticles N-terminal: Addition of dipeptide CG
Sequence
CGYGRKKRRQRRRGC
Physicochemical Analysis
C74H134N36O18S2
ANDEHILMFPSTWV
R
1880.23
12.12
8
0
1
+8
6.03
-2.387
0.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
1615
85.89
4
Residue Composition
number
0
A
6
R
0
N
0
D
2
C
0
E
1
Q
3
G
0
H
0
I
0
L
2
K
0
M
0
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 2 E: 0 Q: 1 G: 3 H: 0 I: 0 L: 0 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
15
C74H134N36O18S2
1880.23
12.12
+8
6.03
-2.387
Addition of dipeptide GC
Hyaluronic acid (HA) conjugated nanoparticles
L
Cationic
Linear
Addition of dipeptide CG
N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Smmc-7721 Cells (3D Mcts)

Assay & Model

Hepatic tumor xenograft model (Balb/c nude mice (4 weeks 18-22g))
Hepatic tumor xenograft model (Balb/c nude mice (4 weeks 18-22g))

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Protein derived
10-hydroxy camptothecin (10-HCPT)
Cytoplasm and nucleus
HA/10-HCPT-NPs without CPPs group, penetrated into the 3D MCTS 2.76-fold thinner than that of the HA/CPPs-10-HCPT-NPs group.
In vitro and in vivo
CCCCCSSSCCCCCCC
Additional Detail Fields 1 fields
CCCCCSSSCCCCCCC