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Peptide record

TPDB92727

n-NTD NTD Cell-penetrating Peptides standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB92727
n-NTD NTD
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD-MOD CPPsite3.0 Peptipedia PerseuCPP
standard
No
A 14-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD-MOD, CPPsite3.0, Peptipedia, and other sources, with an available 3D structural model.
C-terminal: Amidation Chemical: Doxorubicin is attached by a cathepsin B degradable tetrapeptide linker (-Gly-Phe-Leu-Gly-). N-terminal: Acetylation
Sequence
Ac-CGRKKRRQRRRPPQ-NH2
Physicochemical Analysis
C73H136N36O17S1
ANDEHILMFSTWYV
R
1822.17
12.71
8
0
0
+8
8.67
-3.064
0.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
3
Residue Composition
number
0
A
6
R
0
N
0
D
1
C
0
E
2
Q
1
G
0
H
0
I
0
L
2
K
0
M
0
F
2
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 1 E: 0 Q: 2 G: 1 H: 0 I: 0 L: 0 K: 2 M: 0 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
14
C73H136N36O17S1
1822.17
12.71
+8
8.67
-3.064
Amidation
Doxorubicin is attached by a cathepsin B degradable tetrapeptide linker (-Gly-Phe-Leu-Gly-).
L
Cationic
Linear
Acetylation
N[C@@H](CS)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)N)C(=O)O
Evidence Records 2 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HepG2

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Protein derived
Small molecule drug (Doxorubicin)
Lysosome
NTD shows the lower intracellular accumulation concentration
Endocytic pathway
In vitro
CCCTTTCCSSSCCC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

HepG2

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic
Protein derived
Small molecule drug (Doxorubicin)
Lysosome
Lower upatake Efficeincy
Endocytic pathway
In vitro
CCCTTTCCSSSCCC
Additional Detail Fields 1 fields
CCCTTTCCSSSCCC