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Peptide record

TPDB92726

TAT Cell-penetrating Peptides standard
11 amino acids
Basic Information
3D PDB MODEL
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TPDB92726
TAT
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 11-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: Hyaluronate (HA) modified chitosan lactate(CL) nanoparticles (NPs) N-terminal: Addition of Cysteine
Sequence
CGRKKRRQRRR
Physicochemical Analysis
C58H114N32O13S1
ANDEHILMFPSTWYV
R
1499.81
12.71
8
0
0
+8
7.19
-3.291
0.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
2
Residue Composition
number
0
A
6
R
0
N
0
D
1
C
0
E
1
Q
1
G
0
H
0
I
0
L
2
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 1 E: 0 Q: 1 G: 1 H: 0 I: 0 L: 0 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
11
C58H114N32O13S1
1499.81
12.71
+8
7.19
-3.291
Free
Hyaluronate (HA) modified chitosan lactate(CL) nanoparticles (NPs)
L
Linear
Addition of Cysteine
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

4T1 And Ct26 Cancer Cells

Assay & Model

Tumor-bearing BALB/c mice (8 weeks old) mice.
Tumor-bearing BALB/c mice (8 weeks old) mice.

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
FITC-labelled CD73 siRNA and doxorubicin
TAT-HA-conjugated NPs were transfected into about 78% of cancer cells, while free NPs were transfected into only 35% of cancer cells
In vitro and in vivo
CCCCCCCC
Additional Detail Fields 1 fields
CCCCCCCC