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Peptide record

TPDB92722

tLyp-1 Cell-penetrating Peptides Tumor-homing Peptides standard
7 amino acids
Basic Information
3D PDB MODEL
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TPDB92722
tLyp-1
Cell-penetrating Peptides Tumor-homing Peptides
Cancer-related peptides Delivery and barrier-penetrating peptides
CPPsite3.0 Peptipedia PerseuCPP TumorHoPe2.0
standard
No
A 7-aa standard natural multi-activity (Cell-penetrating Peptides and Tumor-homing Peptides) peptide sequence curated from CPPsite3.0, Peptipedia, PerseuCPP, and other sources, with an available 3D structural model.
C-terminal: Amidation
Sequence
CGNKRTR-NH2
Physicochemical Analysis
C31H59N15O10S1
ADEQHILMFPSWYV
R
833.96
11.32
3
0
0
+3
2.94
-2.143
0.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
3
Residue Composition
number
0
A
2
R
1
N
0
D
1
C
0
E
0
Q
1
G
0
H
0
I
0
L
1
K
0
M
0
F
0
P
0
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 1 D: 0 C: 1 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 1 M: 0 F: 0 P: 0 S: 0 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
7
C31H59N15O10S1
833.96
11.32
+3
2.94
-2.143
Amide
Evidence Records 1 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Homing
Breast cancer
Neuropilin-1 (NRP-1)

Source & Reference

TumorHoPe2.0
TumorHoPe2
Self-assembled amphiphilic DNA-cholesterol/DNA-peptide hybrid duplexes with liposome-like structure for doxorubicin delivery
2013
Kyung-Mi Choi et al. Biomaterials. 2013 May 34(16):4183-4190.

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
MDA-MB231 breast cancer cells, HFF human foreskin fibroblast cells
Synthetic
Doxorubicin (DOX), DNA-cholesterol hybrid, DNA-peptide hybrid
Additional Detail Fields 2 fields
Doxorubicin (DOX), DNA-cholesterol hybrid, DNA-peptide hybrid
MDA-MB231 breast cancer cells, HFF human foreskin fibroblast cells