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Peptide record

TPDB92719

TAT Blood-Brain Barrier Cell-penetrating Peptides standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB92719
TAT
Blood-Brain Barrier Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
BBPpredict CPPsite3.0 Peptipedia PerseuCPP
standard
No
A 13-aa standard natural multi-activity (Blood-Brain Barrier and Cell-penetrating Peptides) peptide sequence curated from BBPpredict, CPPsite3.0, Peptipedia, and other sources, with an available 3D structural model.
Chemical: Alexa Fluor® 488-labeled polyethylene glycol derivative APS coated Nanocomplexes
Sequence
CAYGRKKRRQRRR
Physicochemical Analysis
C70H128N34O16S1
NDEHILMFPSTWV
R
1734.06
12.41
8
0
2
+8
6.08
-2.746
7.69
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
1490
85.93
3
Residue Composition
number
1
A
6
R
0
N
0
D
1
C
0
E
1
Q
1
G
0
H
0
I
0
L
2
K
0
M
0
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 6 N: 0 D: 0 C: 1 E: 0 Q: 1 G: 1 H: 0 I: 0 L: 0 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
13
C70H128N34O16S1
1734.06
12.41
+8
6.08
-2.746
Free
Alexa Fluor® 488-labeled polyethylene glycol derivative APS coated Nanocomplexes
L
Cationic
Linear
Free
NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Vk2/E6E7 Human Vaginal Epithelial , Dc 2.4 Cells

Assay & Model

6 to 8 weeks free female BALB/c mice
6 to 8 weeks free female BALB/c mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Protein derived
Recombinant adenovirus rAd-HIVgag
Nearly 95% (6-fold more than rAd particles ) of rAd-TAT and rAd-TAT-APS particles were internalized by VK2/E6E7 cell, Similarly, uptake of rAd-TAT-APS by DC 2.4 cells in the presence of mucus (28%) was significantly higher than uptake of rAd (7%).
Caveolae mediated endocytosis
In vitro and in vivo
CCCCCCTTCC
Additional Detail Fields 1 fields
CCCCCCTTCC