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Peptide record

TPDB92712

CTP (cardiomyocyte-targeting peptide) Cell-penetrating Peptides standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB92712
CTP (cardiomyocyte-targeting peptide)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD CPPsite3.0 Peptipedia
standard
No
A 12-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD, CPPsite3.0, and Peptipedia, with an available 3D structural model.
N-terminal: Thiolated
Sequence
APWHLSSQYSRT
Physicochemical Analysis
C64H93N19O19
NDCEGIKMFV
S
1432.56
9.88
2
0
4
+1
-0.19
-1.042
40.83
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
6990
487.94
6
Residue Composition
number
1
A
1
R
0
N
0
D
0
C
0
E
1
Q
0
G
1
H
0
I
1
L
0
K
0
M
0
F
1
P
3
S
1
T
1
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 1 I: 0 L: 1 K: 0 M: 0 F: 0 P: 1 S: 3 T: 1 W: 1 Y: 1 V: 0
Chemical Descriptors
12
C64H93N19O19
1432.56
9.88
+1
-0.19
-1.042
Free
L
Linear
Thiolated
N[C@@H](Cc1ccccc1)C(=O)/N=C/C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Cardiomyocytes And Myofibroblasts Isolated From Wildtype Sprague Dawley Rat Heart

Assay & Model

Wildtype Sprague Dawley rat heart and Adult male 6-week-old GPs (250–350 g)
Wildtype Sprague Dawley rat heart and Adult male 6-week-old GPs (250–350 g)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Phage Display
Amiodarone drug at N terminus via disulfide linker and Cy5.5 labeled
Cy5.5 labeled CTP showed robust uptake of CTP by cardiomyocytes and negligible co-localization with WGA-488 or uptake of CTP by myofibroblasts
In vivo and ex vivo
CCTTSSCCCCC
Additional Detail Fields 1 fields
CCTTSSCCCCC