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Peptide record

TPDB92709

CTP Cell-penetrating Peptides standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB92709
CTP
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD CPPsite3.0 Peptipedia
standard
No
A 12-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD, CPPsite3.0, and Peptipedia, with an available 3D structural model.
Chemical: HYNIC conjugated at N terminus N-terminal: Conjugated with Cyanine5.5-N-Hydroxysuccinimide (Cy5.5)
Sequence
APWHLSSQYSRT
Physicochemical Analysis
C64H93N19O19
NDCEGIKMFV
S
1432.56
9.88
2
0
4
+1
-0.19
-1.042
40.83
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
6990
487.94
6
Residue Composition
number
1
A
1
R
0
N
0
D
0
C
0
E
1
Q
0
G
1
H
0
I
1
L
0
K
0
M
0
F
1
P
3
S
1
T
1
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 1 I: 0 L: 1 K: 0 M: 0 F: 0 P: 1 S: 3 T: 1 W: 1 Y: 1 V: 0
Chemical Descriptors
12
C64H93N19O19
1432.56
9.88
+1
-0.19
-1.042
Free
HYNIC conjugated at N terminus
L
Linear
Conjugated with Cyanine5.5-N-Hydroxysuccinimide (Cy5.5)
N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)O)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

H9C2 Cells , Ipsc Cell Lines,

Assay & Model

6-8 week-old wild-type CD1 mice
6-8 week-old wild-type CD1 mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Phage Display
Technetium 99m (99mTc) and Cyanine5.5 (Cy5.5) dye
Robust uptake of the peptide at 30 mint
In vitro and in vivo
CCCSSCCCCCC
Additional Detail Fields 1 fields
CCCSSCCCCCC