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Peptide record

TPDB92706

BBBpS_4 Cell-penetrating Peptides standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB92706
BBBpS_4
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD CPPsite3.0 Peptipedia
standard
No
A 12-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD, CPPsite3.0, and Peptipedia, with an available 3D structural model.
C-terminal: Amidation N-terminal: Conjugated with CF
Sequence
APWHLSSQYSRT-NH2
Physicochemical Analysis
C64H93N19O19
NDCEGIKMFV
S
1432.56
9.88
2
0
4
+1
-0.19
-1.042
40.83
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
6990
487.94
6
Residue Composition
number
1
A
1
R
0
N
0
D
0
C
0
E
1
Q
0
G
1
H
0
I
1
L
0
K
0
M
0
F
1
P
3
S
1
T
1
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 1 I: 0 L: 1 K: 0 M: 0 F: 0 P: 1 S: 3 T: 1 W: 1 Y: 1 V: 0
Chemical Descriptors
12
C64H93N19O19
1432.56
9.88
+1
-0.19
-1.042
Amidation
L
Hydrophobic
Linear
Conjugated with CF
N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Hebc-5I, Hs68, HeLa, MDA-MB-231 And Hek-293 Cells

Assay & Model

7-weeks old CD1 female mice
7-weeks old CD1 female mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Hydrophobic
Synthetic
CF dye and Ga-radiolabed for in-vivo
Translocation =33.4 ± 3.5. Lowest uptakes (RFI<10.0).
In vitro and in vivo
CCTTHHHHCCSSCCCCCC
Additional Detail Fields 1 fields
CCTTHHHHCCSSCCCCCC