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Peptide record

TPDB92702

C12-S4(13)-PV C12-S413-PV Cell-penetrating Peptides standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB92702
C12-S4(13)-PV C12-S413-PV
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 21-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation N-terminal: Laurylation
Sequence
ALWKTLLKKVLKAPKKKRKVC-NH2
Physicochemical Analysis
C117H211N33O23S1
NDEQGHIMFSY
K
2480.23
11.32
9
0
9
+9
4.79
-0.438
111.43
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
5500
221.75
2
Residue Composition
number
2
A
1
R
0
N
0
D
1
C
0
E
0
Q
0
G
0
H
0
I
4
L
8
K
0
M
0
F
1
P
0
S
1
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 2 R: 1 N: 0 D: 0 C: 1 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 4 K: 8 M: 0 F: 0 P: 1 S: 0 T: 1 W: 1 Y: 0 V: 2
Chemical Descriptors
21
C117H211N33O23S1
2480.23
11.32
+9
4.79
-0.438
Amidation
L
Cationic
Linear
Laurylation
N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CS)C(=O)O
Evidence Records 2 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

U87 And U87-Gfp Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Chimeric
FAM-labelled siRNA
Cytoplasm
C12-S413-PV is the most competent analog in mediating gene silencing in GBM cells
Endocytosis
In vitro
CTHHHHHHHHTTCCTTCCCCC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

U87 Or U87-Gfp Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Chimeric
DY547-labeled siRNA nanoparticles
The amount of siRNA molecules internalized per cell over time indicated by GMFI, reached the highest values for the H5-S4(13)-PV peptide but reduced to 60% of cells. in 10 % serum.
In vitro
CTHHHHHHHHTTCCTTCCCCC
Additional Detail Fields 1 fields
CTHHHHHHHHTTCCTTCCCCC