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Peptide record

TPDB92695

Ala49 substitution mutant of Tat (49-57) Cell-penetrating Peptides standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB92695
Ala49 substitution mutant of Tat (49-57)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD CPPsite3.0 Peptipedia PerseuCPP
standard
No
A 9-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD, CPPsite3.0, Peptipedia, and other sources, with an available 3D structural model.
N-terminal: Conjugation with fluorescein with 6-aminohexanoic acid (Ahx) spacer
Sequence
AKKRRQRRR
Physicochemical Analysis
C50H99N27O11
NDCEGHILMFPSTWYV
R
1254.51
13.01
7
0
1
+7
6.44
-3.556
11.11
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
1
A
5
R
0
N
0
D
0
C
0
E
1
Q
0
G
0
H
0
I
0
L
2
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 5 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 0 L: 0 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
9
C50H99N27O11
1254.51
13.01
+7
6.44
-3.556
Free
L
Cationic
Linear
Conjugation with fluorescein with 6-aminohexanoic acid (Ahx) spacer
N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Jurkat

Source & Reference

CPPsite3.0
CPPsite3
US 6593292

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Protein derived
Fluorophore (fluorescein)
Probably cytoplasm and nucleus, nucleolus
Low (relative to Tat (49-57))
Probably non-endocytic pathway
In vitro
CTTTTTCCC
Additional Detail Fields 1 fields
CTTTTTCCC