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Peptide record

TPDB92691

NickFect 55 Cell-penetrating Peptides modified_plain modified
22 amino acids
Basic Information
TPDB92691
NickFect 55
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
modified_plain
Yes
A 22-aa modified cell-penetrating peptides peptide sequence curated from CPPsite3.0, without an available 3D structural model.
C-terminal: Amidation N-terminal: Stearylation
Sequence
AGYLLGO*INLKALAALAKAIL-NH2
Physicochemical Analysis
C95H165N23O23
RDCEQHMFPSTWV
AL
1997.50
10.20
2
0
15
+2
-3.52
1.327
169.09
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
1490
74.59
2
Residue Composition
number
6
A
0
R
1
N
0
D
0
C
0
E
0
Q
2
G
0
H
2
I
6
L
2
K
0
M
0
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 6 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 2 L: 6 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
22
C95H165N23O23
1997.50
10.20
+2
-3.52
1.327
Amidation
Modified
Amphipathic
Linear
Stearylation
N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCC(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

CHO-K1, Hek293, Neuro2A And HeLa Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear Modified Amphipathic
Synthetic
EGFP
EGFP signal was detected in the cells, indicating successful transduction of a full, membrane-impermeable protein into mammalian cells.
In vitro
CCCCCCGGGCCSSCCCCC
Additional Detail Fields 1 fields
CCCCCCGGGCCSSCCCCC