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Peptide record

TPDB92688

NF1 Cell-penetrating Peptides standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB92688
NF1
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD-MOD CPPsite3.0 Peptipedia PerseuCPP
standard
No
A 21-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD-MOD, CPPsite3.0, Peptipedia, and other sources, with an available 3D structural model.
C-terminal: Amidation Chemical: Phosphorylated Tyr in the third position N-terminal: Stearylation
Sequence
AGYLLGKTNLKALAALAKKIL-NH2
Physicochemical Analysis
C102H180N26O25
RDCEQHMFPSWV
L
2170.71
10.64
4
0
13
+4
-0.92
0.686
153.81
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
1490
68.64
3
Residue Composition
number
5
A
0
R
1
N
0
D
0
C
0
E
0
Q
2
G
0
H
1
I
6
L
4
K
0
M
0
F
0
P
0
S
1
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 5 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 1 L: 6 K: 4 M: 0 F: 0 P: 0 S: 0 T: 1 W: 0 Y: 1 V: 0
Chemical Descriptors
21
C102H180N26O25
2170.71
10.64
+4
-0.92
0.686
Amidation
Phosphorylated Tyr in the third position
L
Amphipathic
Linear
Stearylation
N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa, U87-Mg, N2A And Ht1080

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
Synthetic
Cy5-labled pDNA
Nucleus
Endocytosis
In vitro
CCSCCCCCCHHHHHHTBTTBC
Additional Detail Fields 1 fields
CCSCCCCCCHHHHHHTBTTBC