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Peptide record

TPDB92687

PF14-O Cell-penetrating Peptides modified_plain modified
21 amino acids
Basic Information
3D PDB MODEL
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TPDB92687
PF14-O
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
modified_plain
Yes
A 21-aa modified cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation Chemical: Nanoparticles N-terminal: Stearylation
Sequence
AGYLLGKLLOOLAOOALOOLL-NH2
Physicochemical Analysis
C76H132N16O17
RNDCEQHIMFPSTWV
L
1541.98
9.74
1
0
12
+1
-4.92
1.419
162.86
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
1490
96.63
1
Residue Composition
number
3
A
0
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
0
I
8
L
1
K
0
M
0
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 3 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 8 K: 1 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
21
C76H132N16O17
1541.98
9.74
+1
-4.92
1.419
Amidation
Nanoparticles
Modified
Linear
Stearylation
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

CHO Cells

Assay & Model

Male and female BALB/c mice (8-week-old)
Male and female BALB/c mice (8-week-old)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Non-natural residues Linear Modified
Synthetic
pDNA (pGL3) and p-CMV-Luc2(pLuc)
Highest gene induction in cell culture was mediated by the vectors that have the highest charge PF14-O (net charge +7) and PF6 (pH-dependent chargen +10), closely followed by PF14 (+5)
In vitro and in vivo