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Peptide record

TPDB92665

PF14 Cell-penetrating Peptides modified_plain modified
21 amino acids
Basic Information
3D PDB MODEL
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TPDB92665
PF14
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
modified_plain
Yes
A 21-aa modified cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation Chemical: Graphene oxide nanosheet N-terminal: Stearylation
Sequence
AGYLLGKLLOOLAAAALOOLL-NH2
Physicochemical Analysis
C82H142N18O19
RNDCEQHIMFPSTWV
L
1684.14
9.74
1
0
14
+1
-5.26
1.590
172.38
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
1490
88.47
1
Residue Composition
number
5
A
0
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
0
I
8
L
1
K
0
M
0
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 5 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 8 K: 1 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
21
C82H142N18O19
1684.14
9.74
+1
-5.26
1.590
Amidation
Graphene oxide nanosheet
Modified
Cationic
Linear
Stearylation
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

U-87 Mg-Luc2, HeLa Pulc 706

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear Modified Cationic
Synthetic
plasmid (pGL3), splice correction oligonucleotides (SCO) or small interfering RNA (siRNA)
1.5–25 fold high penetration for GO-PF14-pGL3 shows compared to pGL3-PF14 for pGL3:GO of 1:1 and 1:0.5.
Scavenger receptor A
In vitro
CCCCCCCC
Additional Detail Fields 1 fields
CCCCCCCC