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Peptide record

TPDB92662

pH low insertion peptide (pHLIP) Cell-penetrating Peptides Tumor-homing Peptides standard
37 amino acids
Basic Information
3D PDB MODEL
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TPDB92662
pH low insertion peptide (pHLIP)
Cell-penetrating Peptides Tumor-homing Peptides
Cancer-related peptides Delivery and barrier-penetrating peptides
CPPsite3.0 TumorHoPe2.0
standard
No
A 37-aa standard natural multi-activity (Cell-penetrating Peptides and Tumor-homing Peptides) peptide sequence curated from CPPsite3.0 and TumorHoPe2.0, with an available 3D structural model.
N-terminal: FITC
Sequence
AEQNPIYWARYADWLFTTPLLLLDLALLVDADEGTCG
Physicochemical Analysis
C193H288N44O57S1
HKMS
L
4168.73
3.32
1
6
20
-5
-0.41
0.281
116.22
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
13980
335.35
8
Residue Composition
number
5
A
1
R
1
N
4
D
1
C
2
E
1
Q
2
G
0
H
1
I
8
L
0
K
0
M
1
F
2
P
0
S
3
T
2
W
2
Y
1
V
Amino Acid Distribution
A: 5 R: 1 N: 1 D: 4 C: 1 E: 2 Q: 1 G: 2 H: 0 I: 1 L: 8 K: 0 M: 0 F: 1 P: 2 S: 0 T: 3 W: 2 Y: 2 V: 1
Chemical Descriptors
37
C193H288N44O57S1
4168.73
3.32
-5
-0.41
0.281
FITC
Evidence Records 1 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Targeting

Source & Reference

TumorHoPe2.0
TumorHoPe2
A smart tumor targeting peptide-drug conjugate, pHLIP-SS-DOX: synthesis and cellular uptake on MCF-7 and MCF-7/Adr cells
2016
Chuan QSX et al. Drug Deliv. 2016 Jun 23(5):1734-46

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
-MCF 7.00
Synthetic
FITC labelled at N-terminus, DOX
Additional Detail Fields 2 fields
FITC labelled at N-terminus, DOX
-MCF 7.00