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Peptide record

TPDB92659

SPACE-EGF Cell-penetrating Peptides standard
11 amino acids
Basic Information
3D PDB MODEL
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TPDB92659
SPACE-EGF
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 11-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: Epidermal Growth Factor (EGF) via glycine-serine linker (GGGGS).
Sequence
ACTGSTQHQCG
Physicochemical Analysis
C40H65N15O17S2
RNDEILKMFPWYV
CQGT
1092.17
7.00
1
0
1
-0
1.90
-0.582
9.09
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
125
11.45
7
Residue Composition
number
1
A
0
R
0
N
0
D
2
C
0
E
2
Q
2
G
1
H
0
I
0
L
0
K
0
M
0
F
0
P
1
S
2
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 2 E: 0 Q: 2 G: 2 H: 1 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 1 T: 2 W: 0 Y: 0 V: 0
Chemical Descriptors
11
C40H65N15O17S2
1092.17
7.00
-0
1.90
-0.582
Free
Epidermal Growth Factor (EGF) via glycine-serine linker (GGGGS).
L
Cyclic
Free
N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

B16 Cells

Assay & Model

tumor-bearing C57BL/6 mice
tumor-bearing C57BL/6 mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Cyclic L
Synthetic
Cy-3-labeled GAPDH siRNA and FITC at N terminal via Ahx linker
The extent of internalization of SPACE-EGF in B16 cells is highest than SPACEand EGF.
In-vitro, in-vivo and ex vivo
CCSSSSCCCC
Additional Detail Fields 1 fields
CCSSSSCCCC